The entourage effect was first introduced in 1998 by Prof. Dr. Raphael Mechoulam, a well-known Israeli cannabis chemist and expert. Prof. Mechoulam is recognized as the foremost innovator and pioneer of cannabis research.
Mechoulam found that natural cannabinoids often had less psychoactive effects, while the beneficial effects of the ingredients seemed stronger. He compared cannabinoids with a variety of active substances (full spectrum
) with cannabinoids in which these substances were isolated and purified (isolates).
Mechoulam concluded that the different components in cannabinoids (full spectrum) work together and respond positively, produce many potential therapeutic effects, and therefore have a greater impact than, for example, isolated CBD (isolate). He gave this the name entourage effect.